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Regulation of NLR stability in plant immunity

Tao WANG, Jiaxin LI, Qian-Hua SHEN

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 2,   Pages 97-104 doi: 10.15302/J-FASE-2018248

Abstract:

Plant nucleotide binding domain and leucine-rich repeat (NLR) receptors recognize pathogen effectors

Keywords： E3 ubiquitin ligase     degradation     nucleotide-binding leucine-rich repeat receptor     plant immunity     proteasome    

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Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 378-388 doi: 10.1007/s11684-021-0840-y

Abstract: The Fc fragment of the IgG-binding protein (FCGBP) was identified as the most promising indicator of

Keywords： severe Mycoplasma pneumoniae pneumonia     children     proteomics     Fc fragment of the IgG-binding protein    

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Chloride binding and time-dependent surface chloride content models for fly ash concrete

S. MUTHULINGAM,B. N. RAO

Frontiers of Structural and Civil Engineering 2016, Volume 10, Issue 1,   Pages 112-120 doi: 10.1007/s11709-015-0322-x

Abstract: fly ash concrete, namely: 1) surface chloride content under tidal exposure condition; and 2) chloride bindingFirst, inconsistencies in surface chloride content and chloride binding models reported in literatureSecondly, to avoid such inconsistencies, surface chloride content and chloride binding models for fly

Keywords： binding isotherms     chloride ingress     concrete     fly ash     surface chloride content    

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Time-domain and frequency-domain approaches to identification of bridge flutter derivatives

Zhengqing CHEN

Frontiers of Structural and Civil Engineering 2009, Volume 3, Issue 2,   Pages 173-179 doi: 10.1007/s11709-009-0034-1

Abstract: method and a frequency-domain method.It was shown that all the flutter derivatives of the thin-plate model identified with the frequency-domainmethod and time-domain method, respectively, agree very well.More precisely, the frequency-domain method usually results in smooth curves of the flutter derivativesThe formulation of time-domain method makes the identification results of flutter derivatives relatively

Keywords： long-span bridges     wind-induced vibration     flutter derivatives     forced vibration test     time-domain method     frequency-domain method    

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Entity and relation extraction with rule-guided dictionary as domain knowledge

Frontiers of Engineering Management   Pages 610-622 doi: 10.1007/s42524-022-0226-0

Abstract: Entity and relation extraction is an indispensable part of domain knowledge graph construction, whichcan serve relevant knowledge needs in a specific domain, such as providing support for product research, sales, risk control, and domain hotspot analysis.However, the performance of these methods degrades when they face domain-specific datasets.To address the problems above, this paper first introduced prior knowledge composed of domain dictionaries

Keywords： entity extraction     relation extraction     prior knowledge     domain rule    

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Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases

Chong Liu, Dingfeng Su

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 35-40 doi: 10.1007/s11684-012-0171-0

Abstract: cholinergic anti-inflammatory pathway,” more specifically via the α7 nicotinic acetylcholine receptor

Keywords： α7 nicotinic acetylcholine receptor     cardiovascular diseases     baroreflex sensitivity    

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reduces IgE binding ability of allergenic egg white proteins

Sen LI, Marina OFFENGENDEN, Michael G. GÄNZLE, Jianping WU

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 3,   Pages 373-381 doi: 10.15302/J-FASE-2018210

Abstract: objective of this study was to investigate the effect of Aspergillus oryzae cultivation on IgE bindingAdding mycelium of A. oryzae ATCC 1011 and 16868 substantially reduced the IgE binding abilityThe binding capacity of egg white proteins to IgE in plasma from four egg allergy patients was almostTherefore, the reduction of IgE binding ability of egg white proteins during A. oryzae treatment

Keywords： Aspergillus oryzae     egg allergy     egg white proteins     IgE-binding ability     ovomucoid    

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Damage identification in connections of moment frames using time domain responses and an optimization

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 4,   Pages 851-866 doi: 10.1007/s11709-021-0739-3

Abstract: study, an optimization-based method for joint damage identification of moment frames using the time-domain

Keywords： damage identification     beam-to-column connection     time-domain response     optimization    

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Quantitative characterization of Cu binding potential of dissolved organic matter (DOM) in sediment from

Yuan ZHANG,Yan ZHANG,Tao YU

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 5,   Pages 666-674 doi: 10.1007/s11783-013-0608-y

Abstract: sediment samples were collected from various part of Taihu Lake to explore the spatial difference in the bindingThe ISE results showed that the exogenous DOM had higher binding ability than endogenous DOM, and DOMderived from aquatic macrophytes had a higher binding ability than that derived from algae.

Keywords： binding ability     dissolved organic matters     fluorescence quenching     complex capacity     Taihu Lake    

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Repression of CDKN2C caused by PML/RARα binding promotes the proliferation and differentiation block

Xiaoling Wang,Yun Tan,Yizhen Li,Jingming Li,Wen Jin,Kankan Wang

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 420-429 doi: 10.1007/s11684-016-0478-3

Abstract: Furthermore, all-trans retinoic acid treatment induced CDKN2C expression by releasing the PML/RARα binding

Keywords： CDKN2C     acute promyelocytic leukemia     cell cycle arrest     differentiation    

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Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies

Peter B. Alexander,Xiao-Fan Wang

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 134-138 doi: 10.1007/s11684-015-0396-9

Abstract: In this review, we discuss the main known mechanisms of resistance to receptor tyrosine kinase inhibitorsoutput, and consider the problems of signaling pathway redundancy and how the activation of different receptor

Keywords： targeted therapy     drug resistance     receptor tyrosine kinases     cancer    

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Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factorreceptor 2-negative (HR

Wenjie Zhu, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 208-220 doi: 10.1007/s11684-020-0795-4

Abstract: New targeted therapies have been developed to overcome resistance to endocrine therapy (ET) and improve the outcome of HR /HER2 advanced breast cancer (ABC). We conducted a meta-analysis and systemic review on randomized controlled trials evaluating various targeted therapies in combination with ET in HR /HER2 ABC. PUBMED and EMBASE databases were searched for eligible trials. Hazard ratios (HRs) for progression-free survival (PFS), odds ratios (ORs) for objective response rate (ORR), clinical benefit rate (CBR), and toxicity were meta-analyzed. Twenty-six studies with data on 10 347 patients were included and pooled. The addition of cyclin-dependent kinase 4/6 inhibitors to ET significantly improved median PFS (pooled HR= 0.547, <0.001), overall survival (pooled HR= 0.755, <0.001), and tumor response rates (ORR, pooled OR= 1.478, <0.001; CBR, pooled OR= 1.201, <0.001) with manageable toxicities (pooled OR= 3.280, <0.001). The mammalian targets of rapamycin inhibitors and exemestane were not clinically beneficial for this pooled population including ET-naïve and ET-resistant patients. Moderate improvement in PFS (pooled HR= 0.686, <0.001) yet pronounced toxicities (pooled OR= 2.154, <0.001) were noted in the combination of phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitors with fulvestrant. Future studies are warranted to optimize the population and the dosing sequence of these available options.

Keywords： endocrine-resistant     HR+/HER2- advanced breast cancer     randomized clinical trials     meta-analysis     targeted therapy    

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microenvironment contributes to tumor progression in diffuse large B-cell lymphoma upon anti-CD19 chimeric antigen receptor

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 699-713 doi: 10.1007/s11684-022-0972-8

Abstract: Anti-CD19 chimeric antigen receptor (CAR)-T cell therapy has achieved 40%–50

Keywords： anti-CD19 chimeric antigen receptor T     immunotherapy     diffuse large B cell lymphoma     tumor microenvironment    

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Terahertz time-domain spectroscopy of high-pressure flames

Jason BASSI, Mark STRINGER, Bob MILES, Yang ZHANG

Frontiers in Energy 2009, Volume 3, Issue 2,   Pages 123-133 doi: 10.1007/s11708-009-0033-x

Abstract: Laser spectroscopy in the visible and near infrared is widely used as a diagnostic tool for combustion devices, but this approach is difficult at high pressures within a sooty flame itself. High soot concentrations render flames opaque to visible light, but they remain transparent to far-infrared or terahertz (THz) radiation. The first far-infrared absorption spectra, to the best of our knowledge, of sooty, non-premixed, ethylene high-pressure flames covering the region of 0.2-2.5 THz is presented. A specially designed high-pressure burner which is optically accessible to THz radiation has been built allowing flame transmission measurements up to pressures of 1.6 MPa. Calculations of the theoretical combustion species absorption spectra in the 0.2-3 THz range have shown that almost all the observable features arise from H O. A few OH (1.84 and 2.51 THz), CH (2.58 THz), and NH (1.77 and 2.95 THz) absorption lines are also observable in principle. A large number of H O absorption lines are observed in the ground vibrational in a laminar non-premixed, sooty flame (ethylene) at pressures up to 1.6 MPa.

Keywords： terahertz time-domain spectroscopy     high-pressure flames     H2O absorption lines    

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Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction with

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 217-226 doi: 10.1007/s11684-014-0326-2

Abstract:

This study was designed to investigate the contribution of miRNA-122-binding site polymorphism at

Keywords： hepatocellular carcinoma (HCC)     interaction     miRNA-122-binding site     IL-1A     rs3783553     hepatitis B virus (    

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Title Author Date Type Operation

Regulation of NLR stability in plant immunity

Tao WANG, Jiaxin LI, Qian-Hua SHEN

Journal Article

Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein

Journal Article

Chloride binding and time-dependent surface chloride content models for fly ash concrete

S. MUTHULINGAM,B. N. RAO

Journal Article

Time-domain and frequency-domain approaches to identification of bridge flutter derivatives

Zhengqing CHEN

Journal Article

Entity and relation extraction with rule-guided dictionary as domain knowledge

Journal Article

Nicotinic acetylcholine receptor α7 subunit: a novel therapeutic target for cardiovascular diseases

Chong Liu, Dingfeng Su

Journal Article

reduces IgE binding ability of allergenic egg white proteins

Sen LI, Marina OFFENGENDEN, Michael G. GÄNZLE, Jianping WU

Journal Article

Damage identification in connections of moment frames using time domain responses and an optimization

Journal Article

Quantitative characterization of Cu binding potential of dissolved organic matter (DOM) in sediment from

Yuan ZHANG,Yan ZHANG,Tao YU

Journal Article

Repression of CDKN2C caused by PML/RARα binding promotes the proliferation and differentiation block

Xiaoling Wang,Yun Tan,Yizhen Li,Jingming Li,Wen Jin,Kankan Wang

Journal Article

Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies

Peter B. Alexander,Xiao-Fan Wang

Journal Article

Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factorreceptor 2-negative (HR

Wenjie Zhu, Binghe Xu

Journal Article

microenvironment contributes to tumor progression in diffuse large B-cell lymphoma upon anti-CD19 chimeric antigen receptor

Journal Article

Terahertz time-domain spectroscopy of high-pressure flames

Jason BASSI, Mark STRINGER, Bob MILES, Yang ZHANG

Journal Article

Association of miRNA-122-binding site polymorphism at the interleukin-1 α gene and its interaction with

Du Yan, Han Xue, Pu Rui, Xie Jiaxin, Zhang Yuwei, Cao Guangwen

Journal Article